Amphetamine is chemically a racemic β–phenylisopropylamine. What is Amphetamine?Īmphetamine is a potent CNS stimulant and an indirect-acting sympathomimetic showing peripheral α and β actions. Amphetamine bioavailability after an oral dose is more than 70% while Methylphenidate bioavailability after an oral dose is round about 30%. Amphetamine has a half-life of 10 hrs on the other hand Methylphenidate has an elimination half-life of 2-3 hrs. Amphetamine causes mental alertness and increases motor activity while Methylphenidate although causes mental alertness but it has less effect on motor activities. MethylphenidateĪmphetamine is a strong CNS stimulant on the other hand, Methylphenidate is a mild CNS stimulant. Proton pump inhibitors, H2 receptor antagonist, Tricyclic AntidepressantsĪripiprazole, Amphetamine, Dextroamphetamine, IbuprofenĪmphetamines or its analogs sensitivity, Thickening of artery walls, Minor or severe Hypertension, Bipolar disordersĪnemia, Manic-depression, Alcoholism, Psychotic disorders, HypertensionĪDVERTISEMENT Amphetamine vs. Methylphenidate is a mild CNS stimulator. Methylphenidate is a schedule II controlled drug. Methylphenidate acts as a dopaminergic drug because it acts as a norepinephrine-dopamine reuptake inhibitor.Īmphetamine is a schedule II controlled drug. Methylphenidate is a mild CNS stimulant, and chemically is a piperidine derivative.Īmphetamine acts as a dopaminergic drug because it acts as a dopamine releasing agent and dopamine reuptake inhibitor. The cost of meth for the amount of euphoria is substantially cheaper in comparison to ecstasy.īoth of these drugs are dangerous, dumb decisions were made on my part, and hopefully, someone else can learn from my mistakes before its too late.ADVERTISEMENT Comparison Chart AmphetamineĪmphetamine is a potent CNS stimulant and an indirect-acting sympathomimetic agent. This direct correlation has led my mind seeing the pipe or syringe as a critical source of dopamine and is likely why I still dream about paraphernalia regularly even seven years since I’ve used anything that has involved a needle or freebase pipe. The immediate rush from the substance immediately crossing the blood-brain barrier makes to the ritual of meth usage directly correlated with an extreme surge of “feel good” neurotransmitters the brain craves as a survival instinct. The route of administration with methamphetamine and cost made it far more addictive, smoking meth or using it intravenously causes an instant peak within seconds. Tolerance can build on long binges However, after hibernation or a tolerance break, the substance comes back just as strong as when you first used it. The ToleranceĮcstasy has a rapid and permanent tolerance build, even a year after ecstasy is used it loses its “magic.” Methamphetamine on the other hand always works. Instead of feeling open to others, you feel more closed off and ego-centric with extreme narcissistic self-confidence that is pleasurable.
Like meth, ecstasy is a stimulant flooding the brain with excitatory neurotransmitters, but meth isn’t as much of an empathogen likely due to the fact it doesn’t increase levels of serotonin as substantially as MDMA.
MDMA is an empathogen – a class of psychoactive drug that induces states of emotional openness, a sense of being connected with others, and feelings of intimacy with oneself and their surroundings. However, the truth is there are far more differences between these two compounds than there are similarities. There’s also a misconception that MDMA would be similar because MDMA stands for 3,4-methylenedioxy- methamphetamine. Meth and MDMA are both often referred to as the most euphoric recreational substances as well. Meth VS MDMA (Ecstasy) is commonly brought up because both substances are phenethylamines. Meth VS MDMA (Ecstasy) Similarities and Differences
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